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Dietary Supplements for Macular Health-Evidence-Based Approach

Evening Symposium

Sponsored by : Bausch + Lomb


17:15 - 18:15

Hall 01

Dietary Supplements for Macular Health-Evidence-Based Approach


Neil Bressler



Leopold Schmetterer, Bora Eldem, Susan Bressler


Age-related macular degeneration (AMD) is the leading cause of irreversible blindness amongst the older population in developed countries. Approximately fty million individuals worldwide are a ected, placing a huge burden on the healthcare system.1 Advanced age and genetic factors are known to increase the risk of developing AMD. Risk factors such as smoking, sunlight exposure and diet are potentially important, as these can be modi ed. We will review these risk factors, how they may be modi ed by lifestyle and diet, and highlight the impact of oxidative stress on the retina.

Antioxidants are used in dietary supplements to presumably reduce oxidative damage to the retina. In the Age- Related Eye Disease Study (AREDS), high doses of vitamin C, E, beta-carotene and zinc demonstrated a bene t in high-risk individuals to reduce progression to advanced AMD. In addition, the carotenoids lutein and zeaxanthin, major components of the macular pigment, have been suggested to be bene cial in other clinical studies.2 The role of antioxidative carotenoids and other dietary supplements as combined in AREDS I and AREDS II to prevent advanced AMD will be explored.

Recent data suggest that antioxidant nutrients also can reduce susceptibility to earlier stages of AMD in those at high genetic risk.3 How the cost e ectiveness of dietary supplements compares favourably with other interventions for preventing AMD-related visual impairment and blindness will be discussed.4

Klein R, et al. Am J Ophthalmol 2004;137:486-95.
Ma L, et al. Br J Nutr 2011:1-10.
3Ho L, et al. Arch Ophthalmol 2011;129:758-66.
4Rein DB, et al. Ophthalmology 2007;114:1319-26.




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